Endocrine Abstracts

Objective: To report a case of a patient diagnosed with latent autoimmune diabetes of adulthood (LADA) based on clinical presentation and positive glutamic acid decarboxylase antibodies (GAD-abs) that converted to antibody negative diabetes after combined treatment with sitagliptin and vitamin D.Methods: A 31-year-old male presented at the emergency room with symptoms of polyuria, polydipsia, and weight loss. Blood glucose was 300 mg/dl with mild ketonur...

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

Introduction: Prevalence of type 2 diabetes mellitus (T2DM) rises rapidly worldwide and most patients with T2DM are obese. All treatment algorithms advocate lifestyle modification and weight loss in combination with various therapeutic categories available for the treatment of T2DM, resulting in diet-antidiabetic drug combinations that are not always proper or safe for the patients.Case presentation: A 73-year-old Caucasian man presented to the emergency...

Background: Previous research suggests an association between specific genetic variations and interindividual variability in response to treatment with glucagon-like receptor agonists (GLP-1 RAs) in patients with type 2 diabetes mellitus (T2DM). We aimed to evaluate the role of CTRB1/2 rs7202877 (T>G) polymorphism in glycemic control and weight loss response to liraglutide among Greek patients with T2DM and to identify clinical factors related to prediction of res...

Background: Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentrations between people living with HIV and healthy controls, as well as to explore potential correlations between the levels of the aforementioned adipokines and markers of calcium h...

Background: Primary hyperparathyroidism (PHPT) has been linked to glucose homeostasis disorders, leading to insulin resistance and type 2 diabetes mellitus. Previous small studies evaluating the effect of parathyroidectomy (PTX) on various parameters of glucose metabolism have produced conflicting results. The impact of PTX on incretin hormone levels has not been studied yet. The aim of this pilot study was to investigate the effect of PTX on markers of glucose metabolism and ...

Background: Orthodox fasting (OF), a periodical vegetarian subset of the Mediterranean diet, has been shown to exert beneficial effects on human health. Athonian fasting is a pescetarian OF variation, where red meat is restricted throughout the year. Previous studies have examined the OF nutritional synthesis and health impact in general population fasters (GF) and Athonian monks (AM), separately. This is the first study to comparatively evaluate the characteristics and effect...

Background: Recent data suggest that disturbances in circadian clock functioning are implicated in the pathogenesis of type 2 diabetes (T2D), through alterations in plasma glucose levels, insulin secretion and sensitivity, energy intake, and genomic expression in liver and pancreas. This study aimed to assess a potential association between variants in clock genes and T2D risk in a population of Greek elderly people.Methods: In a case-control design, 125...

Background: Vitamin D receptor (VDR) in the presence of active calcitriol (1.25--dihydroxy vitamin D) acts as a transcription factor that modulates the gene expression oftransport proteins, which are involved in calcium metabolism. Accumulating evidence suggest apotential implication of vitamin D deficiency in the pathogenesis of diabetes mellitus. We aimed toassess whether variants in the VDR gene contribute to risk of Type 2 Diabetes Mellitus (T2DM).<p class="ab...